Steroid hormone receptors are ligand‐inducible transcription factors that exhibit potent effects on gene expression in living cells. Precise dissection of their mode of action at the molecular level can best be carried out in functional cell‐free systems. This article will describe the benefits of such systems and review their development up to the recent establishment of steroid receptor‐dependent in vitro transcription. Subsequent advances in our knowledge of receptor function arising from the exploitation of this powerful experimental tool will be described. (...) Particular emphasis will be placed upon two key problems: the role of steroid hormone in receptor action and the mechanisms by which steroid receptors activate gene transcription. (shrink)

BackgroundBreast cancer patients are at elevated risk of depression during treatment, thus provoking the chance of poor clinical outcomes. This retrospective cohort study aimed to investigate whether integrating Chinese herbal medicines citation into conventional cancer therapy could decrease the risk of depression in the long-term breast cancer survivors.MethodsA cohort of patients aged 20–70 years and with newly diagnosed breast cancer during 2000–2008 was identified from a nationwide claims database. In this study, we focused solely on survivors of breast cancer at (...) least1 year after diagnosis. After one-to-one matching for age, sex, and baseline comorbidities, breast cancer patients who received and did not receive CHM treatment were enrolled. The incidence rate and hazard ratio citation for depression between the two groups was estimated at the end of 2012. A Cox proportional hazard model was constructed to examine the impact of the CHM use on the risk of depression.ResultsDuring the study period, the incidence rate of depression was significantly lower in the treated cohort than in the untreated cohort [8.57 compared with 11.01 per 1,000 person-years citation], and the adjusted HR remained significant at 0.74 in a Cox proportional hazards regression model. The corresponding risk further decreasing to 43% among those using CHM for more than 1 year.ConclusionFinding from this investigation indicated that the lower risk of depression observed in breast cancer patients treated with CHM, suggesting that CHM treatment should be considered for disease management toward breast cancer. Yet, the optimal administered dose should be determined in further clinical trials. (shrink)

The signature of the formal language of mereology contains only one binary predicate P which stands for the relation “being a part of”. Traditionally, P must be a partial ordering, that is, ${\forall{x}Pxx, \forall{x}\forall{y}((Pxy\land Pyx)\to x=y)}$ and ${\forall{x}\forall{y}\forall{z}((Pxy\land Pyz)\to Pxz))}$ are three basic mereological axioms. The best-known mereological theory is “general extensional mereology”, which is axiomatized by the three basic axioms plus the following axiom and axiom schema: (Strong Supplementation) ${\forall{x}\forall{y}(\neg Pyx\to \exists z(Pzy\land \neg Ozx))}$ , where Oxy means ${\exists (...) z(Pzx\land Pzy)}$ , and (Fusion) ${\exists x\alpha \to \exists z\forall y(Oyz\leftrightarrow \exists x(\alpha \land Oyx))}$ , for any formula α where z and y do not occur free. In this paper, I will show that general extensional mereology is decidable, and will also point out that the decidability of the first-order approximation of the theory of complete Boolean algebras can be shown in the same way. (shrink)